Analiza genetycznych przyczyn niepowodzeń ciÄ Å¼owych u par z poronieniami i urodzeniem dziecka martwego lub żywego z wadami wrodzonymi

Among 59 pairs, the analysis revealed structural aberrations in 7 (11.85%). In one woman with spontaneous abortion, one healthy child and one acranion diagnosed in 18 hbd, a translocation t(3;10)(p25;q21) was identified. The other balanced translocations were present in men: t(4;13)(q34;q31), t(10;22)(p11.2;q13), t(3;14)(p25;q24), t(13;18)(q14;q21.1). In one woman a Robertsonian translocation t(14;21)(q10;q10) was found, an other woman carried an unidentified chromosome 16 aberration. Recognition of causes of reproductive failures make it possible to improve genetic counseling efficacy and prevention of further failures.