کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
10163591 1144074 2016 42 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System
ترجمه فارسی عنوان
مکانیسم های بیرونی و درونی که توسط آن سلول های بنیادی مزانشیمه سیستم ایمنی را مهار می کنند
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی چشم پزشکی
چکیده انگلیسی
Mesenchymal stem cells (MSCs) are a group of fibroblast-like multipotent mesenchymal stromal cells that have the ability to differentiate into osteoblasts, adipocytes, and chondrocytes. Recent studies have demonstrated that MSCs possess a unique ability to exert suppressive and regulatory effects on both adaptive and innate immunity in an autologous and allogeneic manner. A vital step in stem cell transplantation is overcoming the potential graft-versus-host disease, which is a limiting factor to transplantation success. Given that MSCs attain powerful differentiation capabilities and also present immunosuppressive properties, which enable them to survive host immune rejection, MSCs are of great interest. Due to their ability to differentiate into different cell types and to suppress and modulate the immune system, MSCs are being developed for treating a plethora of diseases, including immune disorders. Moreover, in recent years, MSCs have been genetically engineered to treat and sometimes even cure some diseases, and the use of MSCs for cell therapy presents new perspectives for overcoming tissue rejection. In this review, we discuss the potential extrinsic and intrinsic mechanisms that underlie MSCs' unique ability to modulate inflammation, and both innate and adaptive immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Ocular Surface - Volume 14, Issue 2, April 2016, Pages 121-134
نویسندگان
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