Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice

Overexpressing the NH2-terminal fragment of DSPP worsened the periodontal defects in Dspp knockout mice, indicating that the NH2-terminal fragment of DSPP may exert an inhibitory role in the formation and mineralization of hard tissues in the periodontium.