Growth and remodeling of canine common iliac vein in response to venous reflux and hypertension

Chronic venous insufficiency (CVI) affects the venous system of the lower extremities with venous reflux and hypertension. The growth and remodeling of the venous system to the perturbed hemodynamic conditions in CVI are not well understood. The relevance of this study is to provide fundamental data on the morphologic and mechanical properties of the venous system in a translational animal model of CVI. Our findings highlight the adaptive changes of the venous system that may lead to loss of compliance and the various sequelae in CVI.