کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10211245 1646410 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High cycle in vitro hip wear of and in vivo biological response to vitamin E blended highly crosslinked polyethylene
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
High cycle in vitro hip wear of and in vivo biological response to vitamin E blended highly crosslinked polyethylene
چکیده انگلیسی
Wear testing of 40 mm diameter acetabular liners made of vitamin E blended highly-crosslinked polyethylene (VE-HXPE) was conducted for 100 million cycles (Mc) and the wear rate was compared to those of conventional gamma-sterilized polyethylene (CPE) and melt-annealed highly-crosslinked polyethylene (HXPE) liners. Particles of blended VE-HXPE and HXPE particles were injected into the knee capsules of white rabbits to evaluate potential local and systemic effects. VE-HXPE demonstrated volumetric wear rate < 3 mm3/Mc representing an order of magnitude reduction from that of 32 mm diameter CPE liners. The wear debris distribution shifted towards bigger sizes at later stages (>50Mc) of testing, indicating a further reduction in number of particles generated and thus the potential to further reduce the incidence of osteolysis during clinical use. Histological analyses of the liver, spleen and lymph nodes exhibited no evidence of systemic toxicity in rabbits injected with blended VE-HXPE particles. Small clusters of particles were found within synovial membranes and encapsulated in macrophages of rabbits injected with HXPE and VE-HXPE particle suspensions. The degrees of the inflammatory response to VE-HXPE and HXPE particles were not significantly different.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotribology - Volume 16, December 2018, Pages 10-16
نویسندگان
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