کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10211406 1667080 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of tryptophan metabolism and food craving in the relationship between obesity and bipolar disorder
ترجمه فارسی عنوان
نقش متابولیسم تریپتوفان و اشتیاق غذایی در ارتباط بین چاقی و اختلال دوقطبی
کلمات کلیدی
اشتیاق غذایی، شکست تریپتوفان، اضافه وزن، چاقی، اختلال دو قطبی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی
Overweight/obese individuals with BD show an increased driving of tryptophan down the kynurenine pathways, as indicated by an increase in the serum kynurenine-to-tryptophan ratio. The driving of tryptophan down the kynurenine pathway is mediated by immune-inflammatory activity and stress. The correlation of increased kynurenine with food craving, especially carbohydrate craving, probably indicates a regulatory deficit in the maintenance of chronic inflammatory processes in obesity and BD. Food craving seems to be of clinical importance in the treatment of metabolic disturbances in BD, although not associated with anthropometric measures of obesity. Rather, food craving correlates with blood metabolic parameters and an increased activation of the kynurenine pathway, both of which are linked to higher affective symptomatology and the development of cardiovascular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 37, Issue 5, October 2018, Pages 1744-1751
نویسندگان
, , , , , , , , , , , , ,