کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10212311 | 1672214 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Response of NPY immunoreactivity in the tadpole brain exposed to energy rich and energy depleted states
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کلمات کلیدی
AVLNPVpreoptic recessTorus semicircularisNPLSGPTEONDBNRIsMGDnpoSGCNLSNPCAOBSCNNMSLFBNASSGSTadpolelateral forebrain bundle - بسته نرم افزاری پروستات جانبیOptic tectum - سقف نوریaccessory olfactory bulb - لامپ متلاشی کننده لوازم جانبیmedian eminence - مدرنیتهAVM - مرکز خریدNAD - نادانNav - نهnucleus accumbens septi - هسته accumbens septianterior olfactory nucleus - هسته بویایی قدامیventromedial thalamic nucleus - هسته تالامیک ونتومدیالSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکEnergy homeostasis - هومئوستاز انرژیdorsal pallium - پالم پشتیLateral pallium - پالیم جانبیMedial pallium - گوشته جانبیNeuropeptide Y - یوروپروتئین YAON - یکم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY system to positive and negative energy states and elucidate a holistic response of NPY expression throughout the brain of a tadpole model. The pre-metamorphic tadpoles of Euphlyctis cyanophlyctis were subjected to fasting, or intra-cranially injected with glucose or 2-deoxy-d-Glucose (2DG)-a metabolic antagonist of glucose and the response of the NPY system in the entire brain was studied using immunohistochemistry. Glucose injections reduced the basal expression of NPY- immunoreactive perikarya (upto 20%) in the olfactory bulb, nucleus pre-opticus, infundibulum, raphe nucleus and the distal lobe of pituitary. These regions responded to the intracranial injections of 2DG by increasing the expression of NPY up to 30%. Animals deprived of food also possessed the same response except that the increase was much intense in the 2DG injected tadpoles. Our observations lead us to the conclusion that NPY containing neurons in the discrete brain areas may be involved in the maintenance of glucose homeostasis in amphibians and, since these regions also contain the glucose sensing neurons, we further suggest that the release of NPY might be regulated by the glucose sensing neurons of the brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 71, October 2018, Pages 1-10
Journal: Neuropeptides - Volume 71, October 2018, Pages 1-10
نویسندگان
Swapnil Shewale, Ishfaq Ali, Kavita Hadawale, Shobha Bhargava,