کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10227799 461 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds
ترجمه فارسی عنوان
درمان با سلول های سرطانی با استفاده از دوکسوروبیسین که به نانوذرات طلا متصل شده است با استفاده از اوراق قرضه هیدرازون
کلمات کلیدی
سرطان پستان، سلول های بنیادی سرطانی، تحویل مواد مخدر، مقاومت در برابر مواد مخدر، نانوذرات طلا،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Nanoparticle-mediated delivery of chemotherapies has demonstrated enhanced anti-cancer efficacy, mainly through the mechanisms of both passive and active targeting. Herein, we report other than these well-elucidated mechanisms, rationally designed nanoparticles can efficiently deliver drugs to cancer stem cells (CSCs), which in turn contributes significantly to the improved anti-cancer efficacy. We demonstrate that doxorubicin-tethered gold nanoparticles via a poly(ethylene glycol) spacer and an acid-labile hydrazone bond mediate potent doxorubicin delivery to breast CSCs, which reduces their mammosphere formation capacity and their cancer initiation activity, eliciting marked enhancement in tumor growth inhibition in murine models. The drug delivery mediated by the nanoparticles also markedly attenuates tumor growth during off-therapy stage by reducing breast CSCs in tumors, while the therapy with doxorubicin alone conversely evokes an enrichment of breast CSCs. Our findings suggest that with well-designed drug delivery system, the conventional chemotherapeutic agents are promising for cancer stem cell therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 35, Issue 2, January 2014, Pages 836-845
نویسندگان
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