کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10228107 | 473 | 2013 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects
ترجمه فارسی عنوان
لوله های کیتوزان با درجه های مختلف استیلینگ برای جابجایی نقایص عصبی محیطی
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کلمات کلیدی
کیتوزان، راهنمایی عصبی، الکتروفیزیولوژی، هیستومورفومتری، بافت اتصال تنزل،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Biosynthetic nerve grafts are desired as alternative to autologous nerve grafts in peripheral nerve reconstruction. Artificial nerve conduits still have their limitations and are not widely accepted in the clinical setting. Here we report an analysis of fine-tuned chitosan tubes used to reconstruct 10 mm nerve defects in the adult rat. The chitosan tubes displayed low, medium and high degrees of acetylation (DAI: â¼2%, DA: â¼5%, DAIII: â¼20%) and therefore different degradability and microenvironments for the regenerating nerve tissue. Short and long term investigations were performed demonstrating that the chitosan tubes allowed functional and morphological nerve regeneration similar to autologous nerve grafts. Irrespective of the DA growth factor regulation demonstrated to be the same as in controls. Analyses of stereological parameters as well as the immunological tissue response at the implantation site and in the regenerated nerves, revealed that DAI and DAIII chitosan tubes displayed some limitations in the support of axonal regeneration and a high speed of degradation accompanied with low mechanical stability, respectively. The chitosan tubes combine several pre-requisites for a clinical acceptance and DAII chitosan tubes have to be judged as the most supportive for peripheral nerve regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 38, December 2013, Pages 9886-9904
Journal: Biomaterials - Volume 34, Issue 38, December 2013, Pages 9886-9904
نویسندگان
Kirsten Haastert-Talini, Stefano Geuna, Lars B. Dahlin, Cora Meyer, Lena Stenberg, Thomas Freier, Claudia Heimann, Christina Barwig, Luis F.V. Pinto, Stefania Raimondo, Giovanna Gambarotta, Silvina Ribeiro Samy, Nuno Sousa, Antonio J. Salgado,