کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10228191 | 473 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria
ترجمه فارسی عنوان
نانوذرات بیوشیمیایی برای اتصال و نفوذ به باکتری های بیماری زا
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
As an antimicrobial agent, silver nanoparticles functionalized with both bacitracin A and polymyxin E (AgNPs-BA&PE) were designed and synthesized with complementary antibacterial functions to act against gram-positive and gram-negative bacteria. AgNPs-BA&PE could easily get attached and penetrate into the bacterial cell membrane through surface-immobilized BA and PE with a membrane target, resulting in up to 10-fold increase in the antibacterial activity, without the emergence of bacterial resistance. Analysis of the antimicrobial mechanism confirmed that the synthesized nanoparticles caused disorganization of the bacterial cytomembrane and leakage of cytoplasmic contents. This antimicrobial agent with better biocompatibility can promote healing of infected wounds, and has promising and useful applications in biomedical devices and antibacterial control systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 38, December 2013, Pages 10328-10337
Journal: Biomaterials - Volume 34, Issue 38, December 2013, Pages 10328-10337
نویسندگان
Lin Mei, Zhentan Lu, Wei Zhang, Zhongming Wu, Xinge Zhang, Yanan Wang, Yuting Luo, Chaoxing Li, Yanxia Jia,