کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10228217 474 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal blood clot formation induced by temperature responsive polymers by altered fibrin polymerization and platelet binding
ترجمه فارسی عنوان
شکل گیری التهاب غیر طبیعی از طریق پلیمرهای واکنش دهنده دما توسط پلیمریزاسیون فیبرین تغییر یافته و اتصال پلاکتی
کلمات کلیدی
پلیمرهای ترموپلاستیک لخته شدن خون، پلیمریزاسیون فیبرین، پیوند پلاکت، انعقاد خون، لخته فیبرون،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Thermoresponsive polymers (TRPs) have been extensively investigated as smart devices, drug delivery systems and protein conjugates due to their unique phase transition properties. Here, we report the unusual influence of TRPs in blood clotting and the mechanism by which TRPs change the three dimensional organization of blood clot structure. Ten different TRPs with lower critical solution temperatures ranged from 26 to 80 °C are studied. TRPs altered the fibrin polymerization by increasing the rate of protofibril aggregation, decreased the fibrin fiber diameter and changed the platelet integration within the clot. The mechanical properties of the clot decreased considerably in presence of TRPs due to the poor platelet binding. The poor integration of platelets within the clot is not due to the inhibition of platelet activation by TRPs but may due to the unusual organization of fibrin structure. The plasma phase of the blood coagulation is not affected in presence of TRPs. We anticipate that our results will have significant implications on the use of TRPs in applications where blood contact is essential. These observations may also open up new avenues, for example, in the design of new generation antithrombotics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 35, Issue 8, March 2014, Pages 2518-2528
نویسندگان
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