کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10228617 487 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stimulation of angiogenesis, neurogenesis and regeneration by side population cells from dental pulp
ترجمه فارسی عنوان
تحریک انجیوژنز، نوروژنز و باززایی سلول های جانبی از پالپ دندان
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Mesenchymal stem cells (MSCs) have been used for cell therapy in various experimental disease models. However, the regenerative potential of MSCs from different tissue sources and the influence of the tissue niche have not been investigated. In this study, we compared the regenerative potential of dental pulp, bone marrow and adipose tissue-derived CD31− side population (SP) cells isolated from an individual porcine source. Pulp CD31− SP cells expressed the highest levels of angiogenic/neurotrophic factors and had the highest migration activity. Conditioned medium from pulp CD31− SP cells produced potent anti-apoptotic activity and neurite outgrowth, compared to those from bone marrow and adipose CD31− SP cells. Transplantation of pulp CD31− SP cells in a mouse hindlimb ischemia model produced higher blood flow and capillary density than transplantation of bone marrow and adipose CD31− SP cells. Motor function recovery and infarct size reduction were greater with pulp CD31− SP cells. Pulp CD31− SP cells induced maximal angiogenesis, neurogenesis and pulp regeneration in ectopic transplantation models compared to other tissue sources. These results demonstrate that pulp stem cells have higher angiogenic, neurogenic and regenerative potential and may therefore be superior to bone marrow and adipose stem cells for cell therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 8, March 2013, Pages 1888-1897
نویسندگان
, , , , , , , ,