کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10228736 | 495 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats](/preview/png/10228736.png)
چکیده انگلیسی
This study hypothesized that modification of titanium implant surface, e.g. by the deposition of inorganic/organic coatings, can significantly improve the implant-bone response compared in osteoporotic vs. healthy conditions. After osteoporosis was induced in 15 female Wistar rats by ovariectomy (OVX) and confirmed by in vivo micro-CT analysis, implants coated with calcium phosphate (CaP) or collagen type-I and non-coated implants were placed into bilateral femoral condyles. Another 15 sham-operated rats served as controls. Twelve weeks after implantation, micro-CT bone volume (%BV) and histomorphometrical bone area (%BA) were lower around control implants in osteoporotic rats (BV = 60.4%, BA = 43.8%) compared to sham-operated rats (BV = 74.0%, BA = 62.0%). Interestingly, CaP and collagen type-I surface coatings enhanced bone-to-implant contact (%BIC) compared to non-coated implants in osteoporosis (51.9%, 58.2%) as well as in sham-operated (69.7%, 64.4%) groups. The study confirmed that an osteoporotic condition has a significant effect on the amount of bone present in close vicinity to implants. Evidently, the use of osteogenic surface coatings has a favorable effect on the bone implant interface in both osteoporotic and sham-operated conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 15, May 2013, Pages 3747-3757
Journal: Biomaterials - Volume 34, Issue 15, May 2013, Pages 3747-3757
نویسندگان
Hamdan S. Alghamdi, Ruggero Bosco, Jeroen J.J.P. van den Beucken, X. Frank Walboomers, John A. Jansen,