کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10228887 498 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of the osteoblastic and chondrocytic differentiation of stem cells by the extracellular matrix and subsequent bone formation modes
ترجمه فارسی عنوان
مقررات تمایز استئوبلاستیک و کندروسیتی سلول های بنیادی با استفاده از ماتریکس خارج سلولی و سپس فرم های استخوانی
کلمات کلیدی
ماتریکس غیر سلولی، سلول بنیادی، تمایز استئوبلاستیک، تمایز کاندروسیتیک، حالت تشکیل استخوان،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
While various factors have been reported to direct stem cell differentiation lineage, little is known about how nature orchestrates the mesenchymal stem cell (MSC) differentiation and bone morphogenesis during skeleton development and bone regeneration. The present study reports that the matrix has a critical regulating effect on MSC differentiation and the subsequent bone formation modes. A simply combined hydroxyapatite (HA)-collagen matrix stimulates the MSC differentiation into the osteoblastic lineage and leads to a straightforward intramembranous bone formation mode, in contrast to the chondrocytic differentiation and endochondral mode observed on HA-synthetic hydrogel matrix. The accelerated MSC condensation and robust MSC-matrix and MSC-MSC interactions on collagen-based matrix might be the critical factors contributing to such events, likely through the orchestrated signal cascades and cellular events modulated by the extracellular matrix. The results demonstrate that matrix plays critical role in modulating the stem cell differentiation lineage and bone formation mode, which has been largely overlooked.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 28, September 2013, Pages 6580-6588
نویسندگان
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