کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10229281 | 518 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating
ترجمه فارسی عنوان
تعیین اتمیت التهاب ترومبوپروتئین بر سطوح بیومتری با استفاده از پوشش چند دارویی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses triggered when biomaterials or therapeutic cells come into blood contact. We have created a surface which is auto-protective to human innate immunity by combining three fundamentally different strategies, all developed by us previously, which have been shown to induce substantial, but incomplete hemocompatibility when used separately. In summary, we have conjugated a factor H-binding peptide; and an ADP-degrading enzyme; using a PEG linker on both material and cellular surfaces. When exposed to human whole blood, factor H was specifically recruited to the modified surfaces and inhibited complement attack. In addition, activation of platelets and coagulation was efficiently attenuated, by degrading ADP. Thus, by inhibiting thromboinflammation using a multicomponent approach, we have created a hybrid surface with the potential to greatly reduce incompatibility reactions involving biomaterials and transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 4, January 2013, Pages 985-994
Journal: Biomaterials - Volume 34, Issue 4, January 2013, Pages 985-994
نویسندگان
Per H. Nilsson, Kristina N. Ekdahl, Peetra U. Magnusson, Hongchang Qu, Hiroo Iwata, Daniel Ricklin, Jaan Hong, John D. Lambris, Bo Nilsson, Yuji Teramura,