کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10229367 | 521 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration](/preview/png/10229367.png)
چکیده انگلیسی
Management of intestinal failure remains a clinical challenge and total parenteral nutrition, intestinal elongation and/or transplantation are partial solutions. In this study, using a detergent-enzymatic treatment (DET), we optimize in rats a new protocol that creates a natural intestinal scaffold, as a base for developing functional intestinal tissue. After 1 cycle of DET, histological examination and SEM and TEM analyses showed removal of cellular elements with preservation of the native architecture and connective tissue components. Maintenance of biomechanical, adhesion and angiogenic properties were also demonstrated strengthen the idea that matrices obtained using DET may represent a valid support for intestinal regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 12, April 2012, Pages 3401-3410
Journal: Biomaterials - Volume 33, Issue 12, April 2012, Pages 3401-3410
نویسندگان
Giorgia Totonelli, Panagiotis Maghsoudlou, Massimo Garriboli, Johannes Riegler, Giuseppe Orlando, Alan J. Burns, Neil J. Sebire, Virpi V. Smith, Jonathan M. Fishman, Marco Ghionzoli, Mark Turmaine, Martin A. Birchall, Anthony Atala, Shay Soker,