The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine

► We established a human 3D dynamic intestinal tissue model. ► In vitro simulation of the physiological microenvironment of small intestine. ► Defined physical signals support intestinal cell growth and transport behavior. ► Serves as a more reliable preclinical test surface for pharmaceutical substances. ► Our system enables the significant reduction of animal experiments.