کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10229840 549 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and mechanical profiles of native collagen fibers in vaginal wall connective tissues
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Structural and mechanical profiles of native collagen fibers in vaginal wall connective tissues
چکیده انگلیسی
Collagen, an ubiquitous biomaterial, confers robustness and resilience to connective tissues. In this study, we analyzed the structure and elasticity profile of collagen from the vaginal wall connective tissue of healthy pre-menopausal (pre-M) and postmenopausal (post-M) women. The histological staining assisted study with an atomic force microscope renders the examination of native collagen fibers on site of the connective tissue from nanoscopic scale to microscopic scale with high spatial resolution. Our results suggest that during menopause, collagen's structure and elasticity are subject to changes at all levels of organization- between individual collagen fibers, between collagen and muscle, and between collagen and other matrix elements. The systematic analysis of the native structure and mechanical properties of collagen within a tissue provides a potential way to study non-fatal conditions such as pelvic organ prolapse and other genito-urinary disorders, where the initial symptoms are subtle and multivariate, and where early detection of patient's condition may allow better non-invasive interventions and reduce the number of women undergoing surgical correction of these common disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 5, February 2012, Pages 1520-1527
نویسندگان
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