کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10230242 | 787 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formulation and surface modification of poly(ester-anhydride) micro- and nanospheres
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This report presents the formulation and surface modification of poly(ester-anhydride) copolymers. Two synthetic schemes were used to generate a variety of copolymers with varying compositions and molecular weights. These polymers were formulated into both micro- and nanospheres using a water-in-oil-in-water double emulsion technique. Microspheres were between 3 and 10 μm in diameter; whereas, nanospheres were between 300 and 500 nm. Finally, both micro- and nanospheres were surface modified using cystamine and quantified, following cystamine reduction, with DTNB (Ellman's reagent). Surface labeling was observed at 0.20-35 μmol/g for microspheres and 0.6-100 μmol/g for nanospheres and followed the expected trend of increased labeling with increased polyanhydride content.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 2, January 2005, Pages 117-124
Journal: Biomaterials - Volume 26, Issue 2, January 2005, Pages 117-124
نویسندگان
Blaine A Pfeifer, Jason A Burdick, Robert Langer,