کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10301999 | 542543 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of the serotonin transporter gene polymorphism with Korean male alcoholics
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
This study investigated the association between the serotonin transporter polymorphism (5-HTTLPR) and alcoholism in the Korean population. In addition, in order to reduce the clinical heterogeneity, sub-analysis was carried out according to some clinical variables such as a family history of alcoholism, aggressive/violent behavior and the age of onset of alcoholism. One hundred and forty-five patients meeting the DSM-VI criteria for alcohol dependence and 201 healthy controls were examined. Genotyping was performed using a polymerase chain reaction (PCR)-based method. The frequency of the L-allele of 5-HTTLPR was significantly higher in the alcohol dependent patients than in the normal controls (Ï2 = 19.11, df = 1, p < 0.001). Furthermore, there was a significant difference in the allelic distribution between the subgroups defined by a family history of alcoholism (Ï2 = 4.005, df = 1, p = 0.045). This study suggests a putative role of the 5-HTTLPR for alcoholism in the Korean population. However, a replication study with larger different ethnic samples and a refinement of the subtype of alcoholism is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 39, Issue 4, July 2005, Pages 371-376
Journal: Journal of Psychiatric Research - Volume 39, Issue 4, July 2005, Pages 371-376
نویسندگان
Yong Sil Kweon, Hae Kook Lee, Chung Tai Lee, Kyoung-Uk Lee, Chi Un Pae,