کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10301999 542543 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of the serotonin transporter gene polymorphism with Korean male alcoholics
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Association of the serotonin transporter gene polymorphism with Korean male alcoholics
چکیده انگلیسی
This study investigated the association between the serotonin transporter polymorphism (5-HTTLPR) and alcoholism in the Korean population. In addition, in order to reduce the clinical heterogeneity, sub-analysis was carried out according to some clinical variables such as a family history of alcoholism, aggressive/violent behavior and the age of onset of alcoholism. One hundred and forty-five patients meeting the DSM-VI criteria for alcohol dependence and 201 healthy controls were examined. Genotyping was performed using a polymerase chain reaction (PCR)-based method. The frequency of the L-allele of 5-HTTLPR was significantly higher in the alcohol dependent patients than in the normal controls (χ2 = 19.11, df = 1, p < 0.001). Furthermore, there was a significant difference in the allelic distribution between the subgroups defined by a family history of alcoholism (χ2 = 4.005, df = 1, p = 0.045). This study suggests a putative role of the 5-HTTLPR for alcoholism in the Korean population. However, a replication study with larger different ethnic samples and a refinement of the subtype of alcoholism is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 39, Issue 4, July 2005, Pages 371-376
نویسندگان
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