کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10302244 542708 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: An exploratory study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: An exploratory study
چکیده انگلیسی
We report that a group of 7 depressed patients (DP-1) had (1) reduced activation of platelet receptor-stimulated adenylate cyclase by both prostaglandins E2 and D2 compared to controls, and (2) reduced postreceptor stimulation of adenylate cyclase by aluminum fluoride ion in both platelets and mononuclear leukocytes when compared to both another group of depressed patients (DP-2, n = 17) and to controls (n = 21). Our observations in the blood cells of the group DP-1 support the findings of Donati et al. (2008), and they reflect the importance of this interaction between the activated Gsα subunit and membrane lipid microdomains in the pathophysiology and treatment of some major depressive disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 47, Issue 6, June 2013, Pages 706-711
نویسندگان
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