کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10321306 | 659321 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ConsDiff: an algorithm for the detection of conserved differences between protein sequences
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
هوش مصنوعی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: ConsDiff: an algorithm for the detection of conserved differences between protein sequences ConsDiff: an algorithm for the detection of conserved differences between protein sequences](/preview/png/10321306.png)
چکیده انگلیسی
Proteins have been classified into families based on metrics of similarity such as sequence or structural similarity. However, there are significant differences in function even within families. Mapping these differences to individual amino-acid residues is typically done by an expert. This is a subjective and non-scalable approach. ConsDiff is an algorithm that automates this process. It is based on a set of parametric rules using amino-acid substitution matrices and a multiple sequence alignment. This allows the automated discovery of candidate residues that may be responsible for critical differences in function, which may then be experimentally verified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Data & Knowledge Engineering - Volume 53, Issue 1, April 2005, Pages 31-43
Journal: Data & Knowledge Engineering - Volume 53, Issue 1, April 2005, Pages 31-43
نویسندگان
Saumil Mehta, Deendayal Dinakarpandian,