کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10327 679 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons
چکیده انگلیسی

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 28, Issue 10, April 2007, Pages 1918–1925
نویسندگان
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