کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10337143 692569 2009 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A fast, model-independent method for cerebral cortical thickness estimation using MRI
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر گرافیک کامپیوتری و طراحی به کمک کامپیوتر
پیش نمایش صفحه اول مقاله
A fast, model-independent method for cerebral cortical thickness estimation using MRI
چکیده انگلیسی
In this paper we describe an alternative, voxel based technique that measures the cortical thickness using inversion recovery anatomical MR images. Grey matter, white matter and CSF are identified through segmentation, and edge detection is used to identify the boundaries between these tissues. The cortical thickness is then measured along the local 3D surface normal at every voxel on the inner cortical surface. The method was applied to 119 normal volunteers, and validated through extensive comparisons with published measurements of both cortical thickness and rate of thickness change with age. We conclude that the proposed technique is generally faster than deformable model-based alternatives, and free from the possibility of model bias, but suffers no reduction in accuracy. In particular, it will be applicable in data sets showing severe cortical atrophy, where thinning of the gyri leads to points of high curvature, and so the fitting of deformable models is problematic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Image Analysis - Volume 13, Issue 2, April 2009, Pages 269-285
نویسندگان
, , , , ,