A method of 2D/3D registration of a statistical mouse atlas with a planar X-ray projection and an optical photo

► Registration of a statistical mouse atlas with an X-ray projection and a lateral optical photo. ► A statistical mouse atlas for posture and anatomical variations. ► A 2D-registration-back-projection strategy for efficient and accurate atlas deformation. ► Compares favorably to two existing methods, and is robust even with the presence of shoulder tumor.