Differential MRI analysis for quantification of low grade glioma growth

► We propose an original method to quantify differences between two longitudinal brain MRI from the same patient. ► A non-linear Midway intensity mapping & a statistical thresholding framework are presented to process MRI difference maps. ► Optimistic and pessimistic parameterizations were evaluated on FLAIR MRI for the quantification of low-grade glioma growth. ► A clinical study was performed on 32 longitudinal clinical cases from 13 patients. ► Results demonstrate millimetric precision on a specific volumetric radius growth index measurement.