A novel approach for improved tractography and quantitative analysis of probabilistic fibre tracking curves

► Developed a new statistical framework for probabilistic fibre tracking curves. ► Defined methods for probabilistic fibre tracking curve statistics. ► Developed an improved tractography methodology which overcomes a number of limitations of current fibre tracking algorithms. ► A new clustering algorithm for branching curves is developed to separate fibres into branches. ► A quantitative analysis tool for probabilistic tracking methods is introduced using statistical measures of curve-sets.