Automatic multimodal 2D/3D breast image registration using biomechanical FEM models and intensity-based optimization

► Fully automated approach for a 2D/3D breast image registration. ► Two-step simulation of the mammographic compression by the finite element method. ► Patient-specific biomechanical model of the breast. ► FEM-based registration optimized by image similarity metric. ► Evaluation with 79 clinical datasets: clinically relevant registration accuracy.