MRI to X-ray mammography registration using a volume-preserving affine transformation

► Presents a framework for MRI to X-ray mammography registration for clinical use. ► Incorporates an EM-MRF algorithm for breast tissue classification. ► Optimisation of a volume-preserving, affine transformation model. ► Demonstration that an intensity-based approach produces clinically useful accuracy. ► Median accuracy of 13.1 mm when tested on 113 registrations of clinical data sets.