کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10345475 698326 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Explicit solutions for a class of indirect pharmacodynamic response models
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
Explicit solutions for a class of indirect pharmacodynamic response models
چکیده انگلیسی
Explicit solutions for four, ordinary differential equation (ODE)-based, types of indirect response models are presented. These response models were introduced by Dayneka et al. in 1993 [J. Pharmacokinet. Biopharm. 21 (1993) 457] to describe pharmacodynamic responses utilizing inhibitory or stimulatory Emax type functions. The explicit solutions are expressed in terms of hypergeometric 2F1 functions and their analytical continuations. A practical application is demonstrated for modeling the kinetics of drug action for ibandronate, a potent bisphosphonate that suppresses bone turnover resulting in a reduction in the markers of bone turnover. Ten times shorter model evaluation times, with the explicit solution compared with the differential equation implementation, may enhance situations where a large number of model evaluations are needed, such as clinical trial simulations and parameter estimation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 77, Issue 2, February 2005, Pages 91-97
نویسندگان
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