Keywords: غیرممکن; α2-agonists; dexmedetomidine; administration; intranasal; NONMEM;
مقالات ISI غیرممکن (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: غیرممکن; Valsartan; Population pharmacokinetics; Drug-drug interaction; Fixed-dose combination; NONMEM;
Keywords: غیرممکن; Population pharmacokinetics; NONMEM; Atazanavir; Dose optimisation; Thai patients; HIV-infected patients;
Keywords: غیرممکن; Brivaracetam; SV2A; Epilepsy monotherapy; Concentration-effect relationship; Nonlinear mixed effect modeling; NONMEM;
Keywords: غیرممکن; Lithium; Drug compliance; TDM; Population pharmacokinetic analysis; Markov modelling; â2LL; 2xlog(likelihood); BD; bipolar disease; CrCL; creatinine clearance; EBE׳s; Empirical Bayes Estimates; IIV; inter-individual variability; IOV; inter-occasion var
Keywords: غیرممکن; magnesium sulfate; neuroprotection; NONMEM; pharmacokinetics; pregnancy;
Keywords: غیرممکن; Brief-access taste aversion; Lickometer; Bitterness; Emax model; NONMEM; Quinine;
Keywords: غیرممکن; Tuberculosis; Rifampin; Population pharmacokinetics; Antituberculosis agents; NONMEM;
Keywords: غیرممکن; Cefuroxime; Metronidazole; Population pharmacokinetics; Colorectal surgery; PK/PD analysis; Prophylaxis; NONMEM;
Keywords: غیرممکن; digoxin; nonlinear mixed-effects modeling; NONMEM; nutritional status; population pharmacokinetics;
Keywords: غیرممکن; Dropout analysis; Latent Variable; Clinical Trial Simulation; Schizophrenia; PANSS; NONMEM;
Keywords: غیرممکن; Topiramate; Epilepsy; Population pharmacokinetics; NONMEM
Keywords: غیرممکن; Neuropsychiatric impairment; Efavirenz; Continuous time Markov model; NONMEM; Monte Carlo simulation; Duration of NPI
Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation
Keywords: غیرممکن; AUC; area under the curve; BE; bioequivalence; CI; confidence interval; CL; clearance; Cmax; maximum plasma concentration; CR; controlled release; CV; coefficient of variation; f2; similarity factor; FTFF; the fastest tablet of the fastest dissolving form
Population Pharmacokinetics of High-Dose Methotrexate in Patients With Primary Central Nervous System Lymphoma
Keywords: غیرممکن; methotrexate; primary central nervous system lymphoma; population pharmacokinetic model; nonlinear mixed-effects modeling; serum creatinine; body surface area; age; personalized medicine; HDMTX; high-dose methotrexate; MTX; methotrexate; popPK; population
Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes
Keywords: غیرممکن; RO; receptor occupancy; EPS; extrapyramidal symptoms; PK; pharmacokinetic; PD; pharmacodynamic; EM; extensive metabolizer; IM; intermediate metabolizer; PM; poor metabolizer; PBPKPD; physiology-based pharmacokinetic and pharmacodynamic; P-gp; P-glycoprote
A phase 1 study to evaluate the safety and pharmacokinetics of MEDI8852, an anti-influenza A monoclonal antibody, in healthy adult volunteers
Keywords: غیرممکن; MEDI8852; Monoclonal antibody; Influenza; Hemagglutinin; ADA; anti-drug antibodies; AUC0-t; area under the concentrationâtime curve from time 0 to last sampling time point; AUCâ; area under the plasma concentrationâtime curve from time 0 to infinity
Original ResearchA Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Individuals
Keywords: غیرممکن; Population pharmacokinetics; pharmacogenomics; aldehyde dehydrogenase 2; MCMC Bayesian estimation; NONMEM;
Model based population PK-PD analysis of furosemide for BP lowering effect: A comparative study in primary and secondary hypertension
Keywords: غیرممکن; Furosemide; PK-PD modeling; Blood pressure; Anti-hypertensive; Diuretic; NONMEM; (SHR); Spontaneously hypertensive rats; (DOCA-salt rats); Deoxycorticosterone acetate-salt induced hypertensive rats; (PK-PD); Pharmacokinetic-pharmacodynamic; (NONMEM); Nonl
Population Pharmacokinetic/Pharmacodynamics Modeling of Ibutilide in Chinese Healthy Volunteers and Patients With Atrial Fibrillation (AF) and/or Atrial Flutter (AFL)
Keywords: غیرممکن; ibutilide; NONMEM; population PK and PK/PD model; QT interval prolongation; sigmoid Emax model;
A human challenge model for respiratory syncytial virus kinetics, the pharmacological effect of a novel fusion inhibitor, and the modelling of symptoms scores
Keywords: غیرممکن; Pharmacometrics; Respiratory syncytial virus; Pharmacodynamics; Modelling and simulation; Antivirals; NONMEM;
Quelle place pour la modélisation dans les essais cliniques en psychiatrie ?
Keywords: غیرممکن; Modélisation; Pharmacocinétique; Pharmacodynamique; Nonmem; Régression non-linéaire à effets mixtes; LOCF; MMRM; Modeling; Pharmacokinetics; Pharmacodynamic; Nonmem; Non-linear mixed effects modeling; Last Observation Carried Forward;
Pharmacokinetics and biodistribution of squalene-containing emulsion adjuvant following intramuscular injection of H5N1 influenza vaccine in mice
Keywords: غیرممکن; MF59; AS03; Pre-pandemic; NONMEM; Safety; Lymphatic delivery;
A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R
Keywords: غیرممکن; Non-compartmental analysis (NCA); PK; NONMEM; Posterior predictive check; Simulation-based diagnostic;
ADVAN-style analytical solutions for common pharmacokinetic models
Keywords: غیرممکن; ADVAN; Analytical solutions; Intravenous; Methods; Modelling; NONMEM; Oral; Pharmacokinetics; R-language; Simulations
Population pharmacokinetics of ketamine in children with heart disease
Keywords: غیرممکن; Children; Ketamine; Pharmacokinetics; NONMEM
Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study
Keywords: غیرممکن; Adolescent; Antiepileptic drugs; Epilepsy; Perampanel; Post hoc analysis; AE; adverse event; AED; antiepileptic drug; ANCOVA; analysis of covariance; BMI; body mass index; CP; complex partial seizure; ECG; electrocardiogram; EU; European Union; ITT; inten
Predicting the Efficacy of an Oral Paclitaxel Formulation (DHP107) Through Modeling and Simulation
Keywords: غیرممکن; DHP107; paclitaxel; Cancer; NONMEM; Clinical Trial Simulation;
Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus monkeys after iv and sc administration
Keywords: غیرممکن; TFPI; Nonmem; Haemophilia; TMDD; Concizumab; mAb 2021
Population pharmacokinetics of multiple alcohol intake in humans
Keywords: غیرممکن; Ethanol; Population pharmacokinetics; Modeling; Michaelis–Menten kinetics; NONMEM
Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling
Keywords: غیرممکن; Topiramate; Carbamazepine; Renal function; Population pharmacokinetics; NONMEM;
A4S: A user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation
Keywords: غیرممکن; Pharmacokinetic and pharmacodynamic; Compartmental analysis; Tumor Growth Inhibition model; Matlab; Model based drug development; NONMEM
Oxymorphone Active Uptake at the Blood–Brain Barrier and Population Modeling of its Pharmacokinetic–Pharmacodynamic Relationship
Keywords: غیرممکن; Blood brain barrier; active transport; pharmacokinetic/pharmacodynamic models; Microdialysis; HPLC; analgesia; NONMEM; Emax model; censored observations
Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration
Keywords: غیرممکن; Visnagin; Ammi visnaga; Michaelis–Menten kinetics; Nonlinear pharmacokinetics; Nonlinear mixed effect modeling; NONMEM
Structural identifiability analysis and reparameterisation (parameter reduction) of a cardiovascular feedback model
Keywords: غیرممکن; Structural identifiability analysis; Reparameterisation (parameter list reduction); Cardiovascular PKPD model; Parameter estimation; NONMEM; Simulation;
In silico study supports the efficacy of a reduced dose regimen for stavudine
Keywords: غیرممکن; Antiretroviral; Nucleosides; NONMEM; Simulation; HIV; d4T
Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy
Keywords: غیرممکن; Cyclophosphamide; Myeloablative; Children; NONMEM; Pharmacokinetic;
Piraña and PCluster: A modeling environment and cluster infrastructure for NONMEM
Keywords: غیرممکن; NONMEM; Graphical user interface; Cluster; Distributed computing
The influence of drug–drug interaction and patients’ characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling
Keywords: غیرممکن; Valproic acid; Topiramate; Interaction; Therapeutic drug monitoring; Population pharmacokinetics; NONMEM
Evaluation of the nonparametric estimation method in NONMEM VI
Keywords: غیرممکن; Nonparametric estimation method; NONMEM; Parameter distribution estimation; Pharmacokinetics
Semi-mechanistic pharmacodynamic modelling of gene expression and silencing processes
Keywords: غیرممکن; Semi-mechanistic modelling; Gene therapy; Gene expression and silencing; Interferon α; NONMEM
A non-parametric method to analyse time-course of effect in the absence of pharmacokinetic data: Application to inhaled bronchodilators
Keywords: غیرممکن; PKPD modelling; Area under effect curve; NONMEM; Inhaled PKPD; Long-acting beta agonists
Comparison of two types of population pharmacokinetic model structures of paclitaxel
Keywords: غیرممکن; Paclitaxel; Model structure; Observability; NONMEM; Simulation
Efficacy of pulmonary insulin delivery in diabetic rats: Use of a model-based approach in the evaluation of insulin powder formulations
Keywords: غیرممکن; N-Trimethyl chitosan microparticles; Supercritical carbon dioxide; Pulmonary delivery; Insulin; PK-PD modeling; NONMEM
Modeling and simulation of intravenous levetiracetam pharmacokinetic profiles in children to evaluate dose adaptation rules
Keywords: غیرممکن; Epilepsy; Levetiracetam intravenous; Pharmacokinetics; NONMEM; Simulation; Pediatrics
Dose–response population analysis of levetiracetam add-on treatment in refractory epileptic patients with partial onset seizures
Keywords: غیرممکن; Dose–response; Epilepsy; Levetiracetam; Modeling and simulation; NONMEM; Poisson
Population pharmacokinetic model of fluvoxamine in rats: Utility for application in animal behavioral studies
Keywords: غیرممکن; 5-HT; 5-hydroxytryptamine; AUC; area under the curve; BW; bodyweight; CI; confidence interval; CL; systemic clearance; CV; coefficient of variation; CYP; cytochrome P450; DMSO; dimethylsulfoxide; EC50; concentration at the effect site at 50% of the maximu
Effet de l'inhibition des transporteurs OAT1 et MRP2 sur la clairance de l'adéfovir
Keywords: غیرممکن; Transporteurs organiques anioniques; Probénécide; Rats TR-; Clairance rénale; NONMEM; Organic anion transporter; Probenecid; TR- rats; Adefovir clearance; NONMEM;
Estimation of Population Pharmacokinetic Parameters of Free-Phenytoin in Adult Epileptic Patients
Keywords: غیرممکن; Phenytoin; Epilepsy; NONMEM; Oman; Population pharmacokinetics; Protein binding; Michaelis-Menten kinetics;
Explicit solutions for a class of indirect pharmacodynamic response models
Keywords: غیرممکن; Indirect response model; Explicit solution; Hypergeometric function 2F1; NONMEM;