کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9311332 | 1250195 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effet de l'inhibition des transporteurs OAT1 et MRP2 sur la clairance de l'adéfovir
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
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چکیده انگلیسی
Adefovir is transported by the organic anion transporter (OAT1) and the multidrug resistant protein (MRP2, 4 and 5). We studied adefovir clearance in rat after inhibition of transporters by probenecid and in TR- rats, in which MRP2 is lacking. After treatment by probenecid or placebo, pharmacokinetics of adefovir 10 mg/kg was studied via population modeling (NONMEM). The fraction of drug excreted in the urine was low. Renal clearance of adefovir was significantly lower (P < 0.05) in probenecid TR- rats (0.03 ± 0.02 l/hour) than in normal control (0.09 ± 0.05 l/hour), in normal probenecid (0.10 ± 0.07 l/hour) and in TR- control rats (0.13 ± 0.07 l/hour). In vivo in rats MRP2 mutation alone did not affect adefovir clearance suggesting that MRP2 does not play a critical role in the secretion of adefovir. Additional pharmacological inhibition of transporters decreased renal clearance, which may reflect inhibition of compensating transport mechanisms activated when MRP2 is lacking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Néphrologie & Thérapeutique - Volume 1, Issue 5, November 2005, Pages 296-300
Journal: Néphrologie & Thérapeutique - Volume 1, Issue 5, November 2005, Pages 296-300
نویسندگان
Aude Servais, Philippe Lechat, Noël Zahr, Saik Urien, Guy Aymard, Marie Chantal Jaudon, Gilbert Deray, Corinne Isnard Bagnis,