کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667116 1591745 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Population pharmacokinetics and dose optimisation of ritonavir-boosted atazanavir in Thai HIV-infected patients
ترجمه فارسی عنوان
فارماکوکینتیک جمعیت و بهینه سازی دوز از اتاناز ویتاوایسین در بیماران آلوده به تایلندی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


- Population mean clearance (CL/F) of ATV in Thai HIV-infected patients was lower than reported values in other ethnicities.
- ATV CL/F was significantly influenced by sex; male patients had 28.7% higher CL/F compared with females.
- Simulations showed a low dose of ATV/r 200/100 mg once daily provides adequate Ctrough.
- Low-dose ATV/r should be considered for virologically suppressed Thai and Asian patients.

There is evidence that Thai patients receiving standard doses of ritonavir (RTV)-boosted atazanavir (ATV/r) have high exposure to atazanavir (ATV) leading to a higher risk of toxicity. A lower dose of ATV/r may provide adequate exposure in this population. However, pharmacokinetic data on ATV/r in Thai patients required for dose adjustment are limited. This study aimed to develop a population pharmacokinetic model of ATV/r and to determine the influence of patient characteristics on ATV pharmacokinetics. Monte Carlo simulations were performed to estimate the proportion of patients achieving target ATV trough concentration (Ctrough) with the standard ATV/r dose of 300/100 mg and a low dose of 200/100 mg once daily (OD). A total of 127 Thai HIV-infected patients were included in this study. One random blood sample was collected to determine ATV and RTV concentrations at each clinic visit from 100 patients. Intensive data from 27 patients enrolled in previous studies were also included. Data were analysed using the non-linear mixed-effects modelling approach. A one-compartment model with first-order absorption and elimination and absorption lag time best described the data. The population mean clearance of ATV/r was 4.93 L/h in female patients and was 28.7% higher in male patients. Simulation results showed a higher proportion of patients achieving ATV Ctrough within the target range with ATV/r 200/100 mg compared with 300/100 mg. The 200/100 mg OD dose of ATV/r provides adequate ATV exposure in Thai HIV-infected patients. Therefore, a lower dose of ATV/r should be considered for Thai and Asian populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 49, Issue 3, March 2017, Pages 327-332
نویسندگان
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