کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5723139 1608965 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ResearchA Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Individuals
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Original ResearchA Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Individuals
چکیده انگلیسی

BackgroundBlood alcohol concentration data that were previously obtained from 34 healthy Japanese subjects with limited sampling times were reanalyzed. Characteristics of the data were that the concentrations were obtained from only the early part of the time-concentration curve.ObjectiveTo explore significant covariates for the population pharmacokinetic analysis of alcohol by incorporating external data using a Bayesian method, and to estimate effects of the covariates.MethodsThe data were analyzed using a Markov chain Monte Carlo Bayesian estimation with NONMEM 7.3 (ICON Clinical Research LLC, North Wales, Pennsylvania). Informative priors were obtained from the external study.ResultsA 1-compartment model with Michaelis-Menten elimination was used. The typical value for the apparent volume of distribution was 49.3 L at the age of 29.4 years. Volume of distribution was estimated to be 20.4 L smaller in subjects with the ALDH2*1/*2 genotype than in subjects with the ALDH2*1/*1 genotype.ConclusionsA population pharmacokinetic model for alcohol was updated. A Bayesian approach allowed interpretation of significant covariate relationships, even if the current dataset is not informative about all parameters. This is the first study reporting an estimate of the effect of the ALDH2 genotype in a PPK model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Therapeutic Research - Volume 84, 2017, Pages 42-49
نویسندگان
, , , ,