Building a robust, scalable and standards-driven infrastructure for secondary use of EHR data: The SHARPn project

► Innovative technologies to accelerate meaningful use of health care IT are described. ► The SHARPn team is developing an open-source framework for EHR data interoperability. ► Parallel development of tools for patient phenotyping uses standardized EHR data. ► Disparate EHR data were normalized and accessed by a phenotyping rules engine. ► A data throughput test informed design of the framework. Challenges are discussed.