Retinyl palmitate polymeric nanocapsules as carriers of bioactives

► A simple and reproducible poly(d,l-lactide) nanocapsule system. ► A delivery system for retinyl palmitate in association with other bioactives. ► High drug skin permeation from nanocapsules, attributed to their deformability. ► A bimodal distribution of sizes as measured by SANS in shell-matched conditions. ► Different wall thicknesses, where smaller particles show thinner wall thicknesses.