Enhanced adsorption of paracetamol on closed carbon nanotubes by formation of nanoaggregates: Carbon nanotubes as potential materials in hot-melt drug deposition-experiment and simulation

► Paracetamol adsorption on a series of eight closed carbon nanotubes was measured. ► Paracetamol forms nanoaggregates in interstitial channels. ► After heating, nanoaggregates are destroyed and molecules forming them are readsorbed. ► The effect of nanoaggregates formation can be used in hot-melt deposition leading to the formation of new drug delivery system.