Co-delivery of antigen and a lipophilic anti-inflammatory drug to cells via a tailorable nanocarrier emulsion

► Tailorable nanocarrier emulsion (TNE) prepared in simple sequential addition way. ► Auto-immune-relevant antigen coated onto emulsion stabilized by peptide surfactant. ► Lipophilic drug incorporated into the TNE enables auto-immune disease treatments. ► The TNE was internalized by model antigen-presenting cells. ► TNE uptake successfully downregulated the target protein (NF-κB) in macrophages.