Synthesis and characterization of novel thermo-responsive F68 block copolymers with cell-adhesive RGD peptide

► Thermoresponsive and Injectable hydrogels consisting of F68, biodegradable oligomers, 4-META and RGD peptide were successfully synthesized. ► These modified F68 triblock copolymers consist of the PPO blocks core and the PEO blocks shell in aqueous solution. ► The alterations of hydrophobic interaction and chain mobility lead to the phase transition with increasing temperature. ► These hydrogel are anticipated to apply drug delivery and tissue engineering.