Self-assembly of short amyloidogenic peptides at the air-water interface

► The amyloidogenic peptides Ac-DWSFYLLYYTEFT-am (Pβ2m) and Ac-VQIVYK-am (AcPHF6) are surface-active. ► Surface pressure and solvent used for deposition modulate their structures at air-water interface. ► Pβ2m forms fibrils at low surface pressures. At high surface pressures, fibrillar morphology is not discernible. ► AcPHF6 fibrils pack into sheet-like structures at high surface pressures. ► At low surface pressures, AcPHF6 structures show dependence on the solvent used for deposition.