کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10412279 | 894885 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Submicron giant magnetoresistive sensors for biological applications
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
الکتروشیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We have fabricated submicron giant magnetoresistive (GMR) structures and evaluated their sensitivity for biomagnetic applications. GMR devices were fabricated using electron beam lithography, with minimum dimensions below 100ânm. We developed a new characterization technique for these sensors, using a scanned nanoscale magnetic probe and monitoring the resulting response of the sensors. The magnetic field from the scanned probe is similar to that generated by the magnetic particles used to tag bioanalytes. The devices demonstrated extremely high magnetic field resolution. Noise measurements, combined with a local field sensitivity from the scanned probe measurements, predict a sensitivity of 2Ã10â16âemu/Hz1/2 for a magnetic particle 100ânm above the sensor surface. This corresponds to detection of single 100ânm commercially available magnetic labels, which are the lowest size scale of labels now used in biological studies, with a signal-to-noise of unity. Additionally, we predict detection of single 200ânm magnetic labels with a position sensitivity of 93ânm/Hz1/2, allowing proximity detection for particles not directly bound to the sensor surface, with a corresponding signal-to-noise of 10.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators A: Physical - Volume 120, Issue 1, 29 April 2005, Pages 1-6
Journal: Sensors and Actuators A: Physical - Volume 120, Issue 1, 29 April 2005, Pages 1-6
نویسندگان
D.K. Wood, K.K. Ni, D.R. Schmidt, A.N. Cleland,