کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10429228 909700 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain
چکیده انگلیسی
Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer's disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tsinghua Science & Technology - Volume 10, Issue 4, August 2005, Pages 484-488
نویسندگان
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