Keywords: پروتئین پیش ماده آمیلوئید (APP); Familial Alzheimer's disease; Presenilin 1 (PSEN1, PS1); Amyloid precursor protein (APP); White matter hyperintensities; Cerebral amyloid angiopathy;
مقالات ISI پروتئین پیش ماده آمیلوئید (APP) (ترجمه نشده)
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Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease (AD); Lipid rafts; Amyloid precursor protein (APP); Amyloid β (Aβ) peptide; α-, β-, γ-Secretases; Cellular prion protein (PrPC)
The amyloid precursor protein binds to β-catenin and modulates its cellular distribution
Keywords: پروتئین پیش ماده آمیلوئید (APP); APP; amyloid precursor protein; BACE; beta-APP cleaving enzyme; GSK3; Glycogen Synthase Kinase 3; PCP; planar cell polarity; TCF/LEF; T-cell factor/lymphoid enhancer factor; TopFlash; TCL/LEF-Firefly luciferase; Alzheimer's disease; β-catenin; Amyloid
Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane
Keywords: پروتئین پیش ماده آمیلوئید (APP); γ-secretase; Amyloid precursor protein (APP); Molecular dynamics (MD); Synaptic plasma membrane; Cholesterol;
APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer; Amyloid β (Aβ); Amyloid precursor protein (APP); Go protein; Gβγ complex; Degeneration; 3xTg-AD mice;
Alterations of functional circuitry in aging brain and the impact of mutated APP expression
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Fast axonal transport; CA3 of the hippocampus; Dentate gyrus; Transgenic mice for Alzheimer's disease investigation; Aging; Manganese-enhanced magnetic resonance imaging (MEMRI); Cholinergic neurons; Septal nuclei;
Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions
Keywords: پروتئین پیش ماده آمیلوئید (APP); Platelets; Reelin; Thrombus formation; Glycoprotein Ib; Amyloid precursor protein (APP); ApoER2;
(â)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury
Keywords: پروتئین پیش ماده آمیلوئید (APP); (â)-Phenserine; Ischemia/reperfusion injury; Stroke; Middle cerebral artery occlusion (MCAO); Amyloid precursor protein (APP); Brain-derived neurotrophic factor (BDNF); B-cell lymphoma 2 (Bcl-2) expression; Activated-caspase 3; Glial fibrillary acidic p
BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; β-Site APP-cleaving enzyme 1 (BACE1); Amyloid precursor protein (APP); Bcl-2-associated athanogen 1 (BAG-1); NF-κB;
AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Acetylcholinesterase; Amyloid precursor protein (APP); Butyrylcholinesterase; Aβ; amyloid beta; ACh; acetylcholine; AChE; acetylcholinesterase; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BChE; butyrylcho
Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation
Keywords: پروتئین پیش ماده آمیلوئید (APP); Nuclear spheres; Amyloid precursor protein (APP); APP intracellular domain (AICD); APP phosphorylation; APP cleavage; Alzheimer's disease;
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Amyloid-β (Aβ); Amyloid precursor protein (APP); Beta-secretase 1 (BACE1); Tau; Lentivirus; Human brain; APdE9 transgenic mice; Neuroinflammation;
The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb
Keywords: پروتئین پیش ماده آمیلوئید (APP); Cell polarity; Trafficking; Alzheimer disease; Amyloid precursor protein (APP); Amyloid-β (Aβ); Par3; Numb;
Ischemic conditions and β-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells
Keywords: پروتئین پیش ماده آمیلوئید (APP); CNS; central nervous system; AD; Alzheimer's disease; RBE4; rat brain endothelial cell line; OGD; oxygen and glucose deprivation; ogR; oxygen and glucose Restoration; BACE1; amyloid precursor protein (APP) β-secretase; PSEN1; presenilin-1; Aβ; amyloid p
Increased Alzheimer's disease-like pathology in the APP/ PS1ÎE9 mouse model lacking Nrf2 through modulation of autophagy
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Amyloid β peptide; p62/SQSTM; mTOR pathway; Autophagy;
Calcium regulates the interaction of amyloid precursor protein with Homer3 protein
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Amyloid precursor protein (APP); Calcium homeostasis; Homer;
CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Amyloid precursor protein (APP); Amyloid β-peptide (Aβ); γ-Secretase modulator;
The amyloid precursor protein and its homologues: Structural and functional aspects of native and pathogenic oligomerization
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); APLP1; APLP2; Dimer; Homodimerization; Heterodimerization; Structure; Amyloid-beta generation
Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Amyloid precursor protein (APP); Membrane protein; Transmembrane domain; APPTM; HSQC; Micelle; γ-Secretase;
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Object recognition memory; Entorhinal cortex; Hippocampus; Morris water maze; Optokinetic responses; TgCRND8 mice; Spatial memory; Amyloid precursor protein (APP); Brain-derived neurotrophic factor (BDNF); Real Time RT-PCR;
Phosphorylation of LRP1 regulates the interaction with Fe65
Keywords: پروتئین پیش ماده آمیلوئید (APP); Fe65; LDL receptor-related protein 1 (LRP1); Phosphotyrosine binding domain (PTB); NPXY; Phosphorylation; Amyloid precursor protein (APP);
Cu(II) interaction with amyloid-β peptide: A review of neuroactive mechanisms in AD brains
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease (AD); Copper; Amyloid precursor protein (APP); Amyloid-β peptide (Aβ); Reactive oxygen species (ROS); Signal pathway
The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Beta-Site APP cleaving enzyme 1 (BACE1); Low-density lipoprotein receptor-related protein 1 (LRP1); Alzheimer's disease (AD)
Behavioural effects and regulation of PKCα and MAPK by huprine X in middle aged mice
Keywords: پروتئین پیش ماده آمیلوئید (APP); Huprine X; Acetylcholinesterase inhibitors; Learning and memory activation; Aging; Protein kinase Cα (PKCα); Mitogen activated protein kinase (MAPK); Amyloid precursor protein (APP)
Age-related loss of phospholipid asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L human double mutant knock-in mice: Relevance to Alzheimer disease
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Presenilin-1 (PS-1); Familial Alzheimer disease (FAD); Phosphatidylserine (PtdSer); Phospholipid asymmetry; Oxidative stress; Lipid peroxidation; Toxic Aβ(1–42) oligomers; Apoptosis; Caspase-3
Biological markers of amyloid β-related mechanisms in Alzheimer's disease
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease (AD); Alzheimer's Disease Neuroimaging Initiative (ADNI); Amyloid β-peptide (Aβ); Amyloid precursor protein (APP); Biochemical markers; Biomarkers; β-Site APP-cleaving enzyme 1 (BACE1); Cerebrospinal fluid (CSF); Diagnosis; Drug develo
Abnormal cleavage of APP impairs its functions in cell adhesion and migration
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Cell adhesion; Cell migration; Alzheimer’s disease
Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro
Keywords: پروتئین پیش ماده آمیلوئید (APP); Cryptotanshinone; Alzheimer's disease; Amyloid precursor protein (APP); Aβ; α-Secretase;
RNA interference silencing of DRAL affects processing of amyloid precursor protein
Keywords: پروتئین پیش ماده آمیلوئید (APP); α-Secretase; Alzheimer's disease; Amyloid precursor protein (APP); ADAM-10/Kuzbanian; ADAM-17/TACE; DRAL/FHL2/SLIM3
Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease; Amyloid precursor protein (APP); Low density lipoprotein receptor-related protein (LRP); Fluorescence resonance energy transfer (FRET); Fluorescence lifetime imaging microscopy (FLIM);
Impact of cholesterol level upon APP and BACE proximity and APP cleavage
Keywords: پروتئین پیش ماده آمیلوئید (APP); Amyloid precursor protein (APP); Beta-site APP cleaving enzyme (BACE); Total internal reflection microscopy (TIRF); Alzheimer’s disease; Cholesterol
Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-β deposition in N2a cells
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer’s disease; Amyloid precursor protein (APP); Amyloid-β; Myosin II
Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats
Keywords: پروتئین پیش ماده آمیلوئید (APP); Vitamin A deficiency; Retinoic acid nuclear receptor (RAR); Amyloid precursor protein (APP); β-Site APP-cleaving enzyme (BACE); APP carboxy-terminal fragment (CTF); Rat cerebral cortex
Administration of the immunophilin ligand FK506 differentially attenuates neurofilament compaction and impaired axonal transport in injured axons following diffuse traumatic brain injury
Keywords: پروتئین پیش ماده آمیلوئید (APP); Traumatic brain injury; Axonal damage; Amyloid precursor protein (APP); Immunophilin ligands; FK506; Neurofilament compaction (NFC)
Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain
Keywords: پروتئین پیش ماده آمیلوئید (APP); Alzheimer's disease (AD); amyloid precursor protein (APP); stathmin; stathmin-like 2 protein (STMN2); yeast two-hybrid;