کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8293643 1536746 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane
چکیده انگلیسی
Γ-secretase is a membrane-embedded protease that cleaves single transmembrane helical domains of various integral membrane proteins. The amyloid precursor protein (APP) is an important substrate due to its pathological relevance to Alzheimer's disease. The mechanism of the cleavage of APP by γ-secretase that leads to accumulation of Alzheimer's disease causing amyloid-β (Aβ) is still unknown. Coarse-grained molecular dynamics simulations in this study reveal initial lipids raft formation near the catalytic site of γ-secretase as well as changes in dynamic behavior of γ-secretase once interacting with APP. The results suggest a precursor of the APP binding mode and hint at conformational changes of γ-secretase in the nicastrin (NCT) domain upon APP binding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 498, Issue 2, 29 March 2018, Pages 334-341
نویسندگان
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