Keywords: Alzheimer's disease(AD); Amyloid precursor protein(APP); Olfactory system; Olfactory epithelium(OE); γ-Secretase; Presenilin;
مقالات ISI (ترجمه نشده)
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Keywords: Lysosome; γ-Secretase; Intramembrane proteolysis; Signal peptide peptidase-like 2a protease; Alzheimer Disease; CD74;
Keywords: Urothelial cell carcinoma of the urinary bladder; Bladder cancer; Presenilin; γ-Secretase; DAPT;
Keywords: Glioblastoma; Glioma stem cells; Nestin; γ-Secretase;
Keywords: Cholesterol; γ-secretase; MAM; Neurodegeneration; Phospholipids; Presenilin;
Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment
Keywords: CD200; Transcription factor; γ-Secretase; Shedding;
Simulating the γ-secretase enzyme: Recent advances and future directions
Keywords: γ-secretase; Presenilin; Amyloid-β peptide; Alzheimer's disease; Molecular dynamics; Computational approaches;
β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models
Keywords: AICD; FOXO3a; γ-Secretase; Mitochondrial dysfunction; Mitophagy; Parkin; Pink-1; Presenilins; 3xTgAD Mice;
Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse m
Keywords: α7 Nicotinic acetylcholine receptor; Amyloid-β; Microglia; Phagocytosis; Neuron; γ-Secretase;
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease
Keywords: Alzheimer; Amyloid-β; β-Secretase; γ-Secretase; Prevention; Therapy;
Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease
Keywords: γ-Secretase; Alzheimer's disease; Neutron diffraction; Nuclear magnetic resonance; Molecular dynamics; Drug discovery;
Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane
Keywords: γ-secretase; Amyloid precursor protein (APP); Molecular dynamics (MD); Synaptic plasma membrane; Cholesterol;
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway
Keywords: Dioscin; Hepatocyte proliferation; γ-secretase; Liver regeneration; Notch1/Jagged1 signal pathway; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2-deoxy-uridine; CDK2; cyclin D-cyclin dependent kinase 2; CDK4; cyclin D-cyc
Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model
Keywords: Mutant ubiquitin; Ubiquitin-proteasome system; γ-Secretase; Amyloid-β; Behavior; Alzheimer's disease;
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
Keywords: Alzheimer's disease; β-amyloid; β-amyloid precursor protein; γ-secretase; γ-secretase modulator; Notch;
Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ
Keywords: Amyloid-β; γ-secretase; DAPT; Duolink; Neurons; Oligomers;
Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2
Keywords: Alzheimer's disease; ApoER2; γ-Secretase; Lipoprotein receptor; Presenilin; Protein processing; Protein trafficking;
Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein
Keywords: Alzheimer's disease; Amyloid β-protein; Mitochondria; BACE1; γ-secretase; Subcellular fractionation;
Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
Keywords: Intramembrane proteolysis; Signal peptide peptidase; SPPL proteases; ERAD; γ-Secretase; Autoimmunity;
Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest
Keywords: Alzheimer's disease; Presenilin 1 and 2; γ-Secretase; Brain ischemia; Temporal cortex;
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase
Keywords: γ-secretase; Alzheimer's disease; Aβ; Notch;
Featured ArticleChronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b
Keywords: Alzheimer's disease; Chronic hypoxia; β-amyloid; γ-secretase; DNA methylation; DNMT3a; DNMT3b;
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
Keywords: Presenilin; γ-Secretase; Alzheimer's disease; Wnt signalling; Calcium homeostasis; Apoptosis; Protein trafficking; Autophagy;
BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease
Keywords: Amyloid β; γ-Secretase; γ-Secretase modulator; Alzheimer's disease; Amyloid precursor protein;
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease
Keywords: Alzheimer's disease; γ-Secretase; γ-Secretase-modulator; Peroxisome-proliferator-activated-receptor; 5-Lipoxygenase;
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease
Keywords: Neurogranin; CSF biomarker; Plasma biomarker; Prognostic biomarker; Alzheimer's disease; Mild cognitive impairment; tau; Amyloid; γ-secretase; ELISA; Ratio amyloid β;
Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1
Keywords: PS1; presenilin 1; APP; amyloid precursor protein; AD; Alzheimer's disease; NTF; N-terminal Fragment; CTF; C-terminal Fragment; TM; transmembrane domain; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPE; 1-palmitoyl-2-oleoyl-sn-glycero-3-pho
Emerging roles of the γ-secretase-notch axis in inflammation
Keywords: Inflammation; Notch; γ-Secretase; Inflammatory diseases; Stroke; Aβ; amyloid-β; AD; Alzheimer's disease; AICD; APP intracellular domain; ALPS; autoimmune lymphoproliferative syndrome; Aph-1; anterior pharynx-defective 1; ApoE; apolipoprotein E; APP; am
Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
Keywords: Down syndrome; Neonatal pharmacotherapy; APP; AICD; γ-Secretase;
Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain
Keywords: ADAM10; ADAM15; γ-Secretase; HIV-1 replication; Macrophages; CD4+ T lymphocytes; HIV-1 pre-integration complex (PIC); HIV-1 integrase;
Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates
Keywords: Alzheimer's disease; γ-Secretase; Amyloid-β; Cognition;
Podoplanin is a substrate of presenilin-1/γ-secretase
Keywords: PDPN; podoplanin; fl-PDPN; full-length PDPN; EC; extracellular; TM; transmembrane; CT; cytoplasmic; ERM; ezrin radixin moesin; CTF; C-terminal fragment; ICD; intracellular domain; PS; presenilin; MEF; mouse embryonic fibroblast; RIP; regulated intramembra
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; APP/PS1; APPKM670/671NL/PS1L166P transgenic mice; APPKO; amyloid precursor protein knockout mice; Aβ; Amyloid-β peptides; Cofilin1; Cofilin isoform 1; CpdE; Compound E; DIV; days in vitro; DMSO; d
Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA
Keywords: Alzheimer's disease; γ-Secretase; Presenilin 1; Acetylcholinesterase; PRiMA;
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
Keywords: APP; amyloid precursor protein; Aβ; amyloid-β peptide; AICD; amyloid precursor protein intracellular domain; AD; Alzheimer disease; FAD; familial AD; TMD; transmembrane domains; PS; presenilin; NTF; N-terminal fragment; CTF; C-terminal fragment; ER; end
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; CTF; carboxyl-terminal fragment; FTH; ferritin heavy chain; FTL; ferritin light chain; HEK293Swe; HEK293 cells stably expressing human APP Swedish mutations; NICD; notch intracel
Leptin regulates amyloid β production via the γ-secretase complex
Keywords: Leptin; Presenilin; γ-secretase; β-amyloid; Alzheimer's disease;
Basic NeuroscienceAn improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates
Keywords: GSI; γ-secretase inhibitor; GSM; γ-secretase modulator; NICD; Notch intracellular domain; β-Amyloid; Aβ; 2B; 7CHO-2B7; γ-Secretase; Notch; Aβ; Alzheimer's Disease; Modulator; NICD;
Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo
Keywords: Alzheimer's disease; Amyloid β; γ-Secretase; γ-Secretase modulator;
Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Amyloid-β; Adrenergic receptors; Inflammation; Prazosin; γ-Secretase; Mouse brain;
Green tea catechin leads to global improvement among Alzheimer's disease-related phenotypes in NSE/hAPP-C105 Tg mice
Keywords: Catechin; Aβ-42; γ-Secretase; MAPK; Neprilysin; Pin1;
Major Carboxyl Terminal Fragments Generated by γ-Secretase Processing of the Alzheimer Amyloid Precursor Are 50 and 51 Amino Acids Long
Keywords: AICD; Carboxy-terminal fragment (CTF)-γ; amyloid; Alzheimer disease; γ-secretase;
The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells
Keywords: Aβ; amyloidβ-peptide; AD; Alzheimer disease; APP; β-amyloid precursor protein; ESI; electrospray ionization; GAβ; ganglioside-bound Aβ; LC; liquid chromatography; MRM; multiple reaction monitoring; MS; mass spectrometry; MS/MS; tandem mass spectromet
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
Keywords: Alzheimer's disease; γ-Secretase; Aβ42; APP-YAC; In vivo clearance;
Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies
Keywords: Alzheimer's disease; Amyloid precursor protein (APP); Membrane protein; Transmembrane domain; APPTM; HSQC; Micelle; γ-Secretase;
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
Keywords: Acute myeloid leukemia; FLT-3; Kinase inhibitor; γ-Secretase;
Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin
Keywords: Aph-1; Mutagenesis; Nct; PS; Transmembrane domain; γ-secretase;
Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels
Keywords: Alzheimer's disease; Presenilin 1; γ-secretase; Amyloid processing; Acetylcholinesterase; Acetylcholinesterase inhibitor;
Endoplasmic reticulum stress enhances γ-secretase activity
Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; PS; presenilin; ATF4; activating transcription factor 4; GCN2; general control non-derepressible 2; PKR; protein kinase RNA; PERK; PKR-like ER kinase; HRI; heme-regulated inhibitor; eIF2α; eukary
γ-Secretase-mediated growth hormone receptor proteolysis: Mapping of the intramembranous cleavage site
Keywords: GH receptor; γ-Secretase; Cleavage site; Proteolysis;