Intérêt de la coopération ostéoendothéliale en ingénierie du tissu osseux

The techniques of bone tissue engineering, associating autologous repairing cells with a bioactive materials must to take into account of the mechanisms of communication which can exist between the cells requested on the level of a site of repair. Among these phenomenons of interaction, vascularization remains closely related to an osseous regeneration. In vitro studies of co-cultures between endothelials cells and osteoblastic cells of various origins let predict existence of different factors (growth factors, peptides natriuretic, nitric oxyde) but also of junction communication responsible for the regulation of the bone formation activity of the osteogenic cells. In addition, the existence of such cooperation could be demonstrated using experimental models of osseous reconstruction. Finally, the contribution of the nanotechnologies of the biomaterials offers very promising prospects to promote these cellular cooperations and these heterotopic communications.