کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10431813 910226 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improving the clinical efficiency of T2⁎ mapping of ligament integrity
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Improving the clinical efficiency of T2⁎ mapping of ligament integrity
چکیده انگلیسی
Current MR methods use T2⁎ relaxation time as a surrogate measure of ligament strength. Currently, a multi-echo voxel-wise least squares fit is the gold standard to create T2⁎ maps; however, the post-processing is time-intensive and serves as a stopgap for clinical use. The study objective was to determine if an alternative method could improve post-processing time without sacrificing fidelity of T2⁎ values for eventual translational use in the clinic. Using a 6 echo FLASH sequence, three different methods were used to determine intact posterior cruciate ligament (PCL) median T2⁎ Two of these methods utilized a voxel-wise method to establish T2⁎ maps: (1) a current “gold standard” method using a voxel-wise 6 echo least-squares fit (6LS) and (2) a voxel-wise 2 echo point T2⁎ determination (2MM). The third method used median ligament signal intensity and a single nonlinear least-squares fit (6LSROI) instead of a voxel-wise basis. The resulting median T2⁎ values of the PCL and computational time were compared. The median T2⁎ values were 42% higher using the 2MM compared to the 6LS method (p<0.0001). However, a strong correlation was found for the median T2⁎ values between the 2MM and 6LS methods (R2=0.80). The median T2⁎ values were not significantly different between the 6LS and 6LSROI methods (p=0.519). Using the 2MM (which provides a regional map) and the 6LSROI (which efficiently provides the median T2⁎ value) methods in tandem would take only minutes of post-processing computational time compared to the 6LS method (~540 min), and hence would facilitate clinical application of T2⁎ maps to predict ligament structural properties as a patient outcome measure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 47, Issue 10, 18 July 2014, Pages 2522-2525
نویسندگان
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