کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10432199 910239 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium
چکیده انگلیسی
Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair bundle towards the tallest row of stereocilia causes increased probability of opening of ion channels. In this work, we focus on one of the physical features of the OHC stereocilium, the initial insertion angle of the tallest row into the tectorial membrane (TM), and its effects on the stereocilia's deflection motion. A three-dimensional model was built for the tallest stereocilium and the TM at the region where the best frequency was 500 Hz. The mechanical interactions between the embedded stereocilia and the TM have been implemented into the finite element simulation. We found that, the optimum insertion angle of the tallest stereocilium into the TM was 69.8°, where the stereocilium is maximally deflected. This quantity is consistent with the histological observation obtained from the literature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 45, Issue 10, 26 June 2012, Pages 1823-1827
نویسندگان
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