کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10432220 910240 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Numerical simulation of arterial dissection during balloon angioplasty of atherosclerotic coronary arteries
ترجمه فارسی عنوان
شبیه سازی عددی جداسازی شریانی در طی آنژیوپلاستی بالون شریان های کرونر آترواسکلروز
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Balloon angioplasty is a standard clinical treatment for symptomatic coronary artery disease. In this procedure, controlled damage is applied intraluminally to the wall of a stenotic artery. Dissection of the coronary artery is a commonly observed clinical complication of angioplasty; however, not all dissections can be detected angioscopically. This work focuses on studying the dissection mechanisms triggered during the early stages of angioplasty in an atherosclerotic coronary artery, addressing the problem by means of a parametric study based on a simplified finite element model and cohesive interface modeling. Our results emphasize the presence of several damage mechanisms, at different locations, that are triggered near the very beginning of the process and evolve competitively, depending on both geometry and material properties of the atherosclerotic vessel. Small-scale damage was evidenced, which would not be detectable by angiography or intravascular ultrasound, but could potentially be sufficient to stimulate smooth muscle cell activation, promoting late-onset complications such as restenosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 47, Issue 4, 3 March 2014, Pages 878-889
نویسندگان
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