The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta

Collagen remodeling is present following 14 days of AngII infusion in C57BL/6 mice. Aneurysmal development occurred in 50% of our AngII infused mice, and these dilatations were accompanied with adventitial collagen remodeling and decreased circumferential compliance.